A mouse model of single and repetitive mild traumatic brain injury

Bevan S. Main, Stephanie S. Sloley, Sonia Villapol, David N. Zapple, Mark P. Burns

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Mild Traumatic Brain Injury (mTBI) can result in the acute loss of brain function, including a period of confusion, a loss of consciousness (LOC), focal neurological deficits and even amnesia. Athletes participating in contact sports are at high risk of exposure to large number of mTBIs. In terms of the level of injury in a sporting athlete, a mTBI is defined as a mild injury that does not cause gross pathological changes, but does cause short-term neurological deficits that are spontaneously resolved. Despite previous attempts to model mTBI in mice and rats, many have reported gross adverse effects including skull fractures, intracerebral bleeding, axonal injury and neuronal cell death. Herein, we describe our highly reproducible animal model of mTBI that reproduces clinically relevant symptoms. This model uses a custom made pneumatic impactor device to deliver a closed-head trauma. This impact is made under precise velocity and deformation parameters, creating a reliable and reproducible model to examine the mechanisms that contribute to effects of single or repetitive concussive mTBI.

Original languageEnglish (US)
Article numbere55713
JournalJournal of Visualized Experiments
Issue number124
StatePublished - Jun 20 2017


  • Concussion
  • Injury
  • Issue 124
  • Loss of consciousness
  • Medicine
  • Mild traumatic brain injury (mTBI)
  • Neuroscience
  • Repetitive head trauma

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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