A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice

Y. Wang, Z. Zhang, R. A. Lubet, M. You

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Although ras and p53 are the most commonly found oncogene and tumor suppressor gene, respectively, in human cancers, their collective roles in tumor progression have yet to be defined in animal models. Here, we demonstrated the synergistic effect between ras and p53 in promoting tumor progression during lung tumorigenesis using bitransgenic mice. Mice with a heterozygous knockout of K-ras (K-raswt/ko) were mated to p53 transgenic mice (p53 val135/wt) in lung tumorigenesis (K-raswt/ko × p53val135/wt). F1 mice exhibited a significant increase in lung tumor load (tumor multiplicity x tumor volume) when compared to those seen in either K-raswt/ko mice or p53val135/wt mice alone. Furthermore, over 50% of the lung tumors were lung adenocarcinomas in bitransgenic mice compared to only 3% in wild-type mice. Alterations of ras and p53 appear to promote the development of lung adenocarcinomas. These results provide the in vivo experimental evidence of synergistic interactions of ras and p53 in lung tumor progression.

Original languageEnglish (US)
Pages (from-to)1277-1280
Number of pages4
JournalOncogene
Volume25
Issue number8
DOIs
StatePublished - Feb 23 2006

Keywords

  • Cancer
  • Lung
  • Progression
  • Ras
  • Transgenic mice
  • p53

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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