TY - JOUR
T1 - A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes
AU - Ceci, Jeffrey D.
AU - Siracusa, Linda D.
AU - Jenkins, Nancy A.
AU - Copeland, Neal G.
N1 - Funding Information:
We are grateful to T. Yamamoto for the Lyn probe. G. Vande Woude for Mos, I. Kourides for Tsha, W. Held for Mup-1, L. The-lander for Rrm2, P. Pitha-Rowe for Zfa, T. Bos and P. Vogt for Jun, K. Huppi for Lmyc, R. Perlmutter for Lck, M. Bishop for Fgr, D. Steffen for Dsi-1, and .J. Mullins for Anf. We thank D. A. Swing, C. M. Silan, M. Bodamer, J. Dietz, and B. Eagleson for providing excellent technical assistance. We thank T. H. Roderick. M. T. Da-v&on, A. L. Hillyard, and D. P. Doolittle for sharing their resources with us. The composite genetic linkage map was compiled using GBASE. a computerized data base maintained at The Jackson Laboratory (Bar Harbor, Maine). This research was supported by the National Cancer Institute. DHHS, under Contract NOl-CO-74101 with BRI. The NCI-Frederick Cancer Research Facility is fully accredited by the American Association for Accreditation of Laboratory Animal Care. L.D.S. is the recipient of a National Research Service Award, Postdoctoral Fellowship GM 12721-01.
PY - 1989/11
Y1 - 1989/11
N2 - We have constructed a 64-cM molecular genetic linkage map of mouse chromosome 4 using interspecific backcross animals derived from mating C57BL 6J and Mus spretus mice. Several proto-oncogenes and common sites of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lek, Fgr, and Dsi-1. Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf. A comparison of our mapping data with inbred strain mapping data did not show any evidence for inversions or deletions on chromosome 4. New regions of synteny were defined between mouse chromosome 4 and human chromosomes 1 and 8; a region of homology was found between mouse chromosome 4 and human chromosome 6. This linkage map will provide a framework for identifying homologous genes in mice and humans that may be involved in various disease processes.
AB - We have constructed a 64-cM molecular genetic linkage map of mouse chromosome 4 using interspecific backcross animals derived from mating C57BL 6J and Mus spretus mice. Several proto-oncogenes and common sites of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lek, Fgr, and Dsi-1. Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf. A comparison of our mapping data with inbred strain mapping data did not show any evidence for inversions or deletions on chromosome 4. New regions of synteny were defined between mouse chromosome 4 and human chromosomes 1 and 8; a region of homology was found between mouse chromosome 4 and human chromosome 6. This linkage map will provide a framework for identifying homologous genes in mice and humans that may be involved in various disease processes.
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U2 - 10.1016/0888-7543(89)90111-0
DO - 10.1016/0888-7543(89)90111-0
M3 - Article
C2 - 2574141
AN - SCOPUS:0024757023
SN - 0888-7543
VL - 5
SP - 699
EP - 709
JO - Genomics
JF - Genomics
IS - 4
ER -