A molecular genetic linkage map of mouse chromosome 2

Linda D. Siracusa, Colleen M. Silan, Monica J. Justice, John A. Mercer, Asne R. Bauskin, Yinon Ben-Neriah, Denis Duboule, Nicholas D. Hastie, Neal G. Copeland, Nancy A. Jenkins

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Interspecific backcross mice were used to create a molecular genetic linkage map of chromosome 2. Genomic DNAs from N2 progeny were subjected to Southern blot analysis using molecular probes that identified the Abl, Acra, Ass, C5, Cas-1, Fshb, Geg, Hox-5.1, Jgf-1, Kras-3, Ltk, Pax-1, Prn-p, and Spna-2 loci; these loci were added to the 11 loci previously mapped to the distal region of chromosome 2 in the same interspecific backcross to generate a composite multilocus linkage map. Several loci mapped near, and may be the same as, known mutations. Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed.

Original languageEnglish (US)
Pages (from-to)491-504
Number of pages14
JournalGenomics
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Genetics

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