TY - JOUR
T1 - A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18
AU - Justice, Monica J.
AU - Gilbert, Bebra J.
AU - Kinzler, Kenneth W.
AU - Vogelstein, Bert
AU - Buchberg, Authur M.
AU - Ceci, Jeffrey D.
AU - Matsuda, Yoichi
AU - Chapman, Verne M.
AU - Patriotis, Christos
AU - Makris, Antonios
AU - Tsichlis, Philip N.
AU - Jenkins, Nancy A.
AU - Copeland, Neal G.
N1 - Funding Information:
Sakaki, and U. Drager for kindly providing their resources. We thank Dr. J. Testa, Dr. W. F. Dove, Dr. A. K. Moser, and C. Luongo for providing information prior to its publication. D. S. Swing, B. C. Cho, and M. E. Barnstead are thanked for providing excellent technical assistance. We thank Dr. L. F. Lock for critically reviewing the manuscript. This research was supported, in part, by the National Cancer Institute, DHHS, under Contract NOl-CO-74101 with ABL. M. J. J. is the recipient of a National Research Service Award, Postdoctoral Fellowship 5F32CA088.53.03.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/8
Y1 - 1992/8
N2 - An interspecific backcross between C57BL 6J and Mus spretus was used to generate a molecular genetic linkage map of mouse chromosome 18 that includes 23 molecular markers and spans approximately 86% of the estimated length of the chromosome. The Apc, Camk2a, D18Fcr1, D18Fcr2, D18Leh1, D18Leh2, Dcc, Emb-rs3, Fgfa, Fim-2 Csfmr, Gnal, Grl-1, Grp, Hk-1rsI, Ii, Kns, Lmnb, Mbp, Mcc, Mtv-38, Palb, Pdgfrb, and Tpl-2 genes were mapped relative to each other in one interspecific backcross. A second interspecific backcross and a centromere-specific DNA satellite probe were used to determine the distance of the most proximal chromosome 18 marker to the centromere. The interspecific map extends the known regions of linkage homology between mouse chromosome 18 and human chromosomes 5 and 18 and identifies a new homology segment with human chromosome 10p. It also provides molecular access to many regions of mouse chromosome 18 for the first time.
AB - An interspecific backcross between C57BL 6J and Mus spretus was used to generate a molecular genetic linkage map of mouse chromosome 18 that includes 23 molecular markers and spans approximately 86% of the estimated length of the chromosome. The Apc, Camk2a, D18Fcr1, D18Fcr2, D18Leh1, D18Leh2, Dcc, Emb-rs3, Fgfa, Fim-2 Csfmr, Gnal, Grl-1, Grp, Hk-1rsI, Ii, Kns, Lmnb, Mbp, Mcc, Mtv-38, Palb, Pdgfrb, and Tpl-2 genes were mapped relative to each other in one interspecific backcross. A second interspecific backcross and a centromere-specific DNA satellite probe were used to determine the distance of the most proximal chromosome 18 marker to the centromere. The interspecific map extends the known regions of linkage homology between mouse chromosome 18 and human chromosomes 5 and 18 and identifies a new homology segment with human chromosome 10p. It also provides molecular access to many regions of mouse chromosome 18 for the first time.
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U2 - 10.1016/0888-7543(92)90047-V
DO - 10.1016/0888-7543(92)90047-V
M3 - Article
C2 - 1354644
AN - SCOPUS:0026674407
SN - 0888-7543
VL - 13
SP - 1281
EP - 1288
JO - Genomics
JF - Genomics
IS - 4
ER -