A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci

Monica J. Justice, Colleen M. Silan, Jeffrey D. Ceci, Arthur M. Buchberg, Neal G. Copeland, Nancy A. Jenkins

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A molecular genetic linkage map of mouse chromosome 13 was constructed using cloned DNA markers and interspecific backcross mice from two independent crosses. The map locations of Ctla-3, Dhfr, Fim-1, 4 12, Hexb, Hilda, Inhba, Lamb-1.13, Ral, Rrm2-ps3, and Tcrg were determined with respect to the beige (bg) and satin (sa) loci. The map locations of these genes confirm and extend regions of homology between mouse chromosome 13 and human chromosomes 5 and 7, and identify a region of homology between mouse chromosome 13 and human chromosome 6. The molecular genetic linkage map of chromosome 13 provides a framework for establishing linkage relationships between cloned DNA markers and known mouse mutations and for identifying homologous genes in mice and humans that may be involved in disease processes.

Original languageEnglish (US)
Pages (from-to)341-351
Number of pages11
JournalGenomics
Volume6
Issue number2
DOIs
StatePublished - Feb 1990

ASJC Scopus subject areas

  • Genetics

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