TY - JOUR
T1 - A molecular analysis of NKT cells
T2 - Identification of a class-I restricted T cell-associated molecule (CRTAM)
AU - Kennedy, J.
AU - Vicari, A. P.
AU - Saylor, V.
AU - Zurawski, S. M.
AU - Copeland, Neal G.
AU - Gilbert, D. J.
AU - Jenkins, Nancy A.
AU - Zlotnik, A.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - cDNA library subtraction techniques were used to identify transcripts expressed by activated mouse αβTCR+ CD4-CD8- (double-negative; DN) T cells, a subset of natural killer T (NKT) cells. The most frequent cDNAs identified included the chemokines TCA3, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, and lymphotactin (LPTN), the cytokines interleukin-4 (IL-4) and interferon-γ (IFN-γ), and a granzyme. We also identified a new member of the immunoglobulin superfamily (Ig-SF). This molecule was designated class I-restricted T cell-associated molecule (CRTAM) as a result of its restricted expression pattern in T cells. Human CRTAM was also identified, and shares the same expression pattern as the mouse molecule. LPTN and CRTAM exhibit the same expression pattern in T cells, suggesting the existence of a gene expression program common to class I-MHC-restricted T cells.
AB - cDNA library subtraction techniques were used to identify transcripts expressed by activated mouse αβTCR+ CD4-CD8- (double-negative; DN) T cells, a subset of natural killer T (NKT) cells. The most frequent cDNAs identified included the chemokines TCA3, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, and lymphotactin (LPTN), the cytokines interleukin-4 (IL-4) and interferon-γ (IFN-γ), and a granzyme. We also identified a new member of the immunoglobulin superfamily (Ig-SF). This molecule was designated class I-restricted T cell-associated molecule (CRTAM) as a result of its restricted expression pattern in T cells. Human CRTAM was also identified, and shares the same expression pattern as the mouse molecule. LPTN and CRTAM exhibit the same expression pattern in T cells, suggesting the existence of a gene expression program common to class I-MHC-restricted T cells.
KW - Cell-surface molecules
KW - Human
KW - Mouse
KW - T lymphocytes
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U2 - 10.1002/jlb.67.5.725
DO - 10.1002/jlb.67.5.725
M3 - Article
C2 - 10811014
AN - SCOPUS:0033848982
VL - 67
SP - 725
EP - 734
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 5
ER -