A molecular analysis of NKT cells: Identification of a class-I restricted T cell-associated molecule (CRTAM)

J. Kennedy, A. P. Vicari, V. Saylor, S. M. Zurawski, Neal G. Copeland, D. J. Gilbert, Nancy A. Jenkins, A. Zlotnik

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

cDNA library subtraction techniques were used to identify transcripts expressed by activated mouse αβTCR+ CD4-CD8- (double-negative; DN) T cells, a subset of natural killer T (NKT) cells. The most frequent cDNAs identified included the chemokines TCA3, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, and lymphotactin (LPTN), the cytokines interleukin-4 (IL-4) and interferon-γ (IFN-γ), and a granzyme. We also identified a new member of the immunoglobulin superfamily (Ig-SF). This molecule was designated class I-restricted T cell-associated molecule (CRTAM) as a result of its restricted expression pattern in T cells. Human CRTAM was also identified, and shares the same expression pattern as the mouse molecule. LPTN and CRTAM exhibit the same expression pattern in T cells, suggesting the existence of a gene expression program common to class I-MHC-restricted T cells.

Original languageEnglish (US)
Pages (from-to)725-734
Number of pages10
JournalJournal of Leukocyte Biology
Volume67
Issue number5
DOIs
StatePublished - Jan 1 2000

Keywords

  • Cell-surface molecules
  • Human
  • Mouse
  • T lymphocytes

ASJC Scopus subject areas

  • Cell Biology

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