A model-based approach to investigate the effect of a long bone fracture on ultrasound strain elastography

Songyuan Tang, Eric P. Sabonghy, Anuj Chaudhry, Peer Shafeeq Shajudeen, Md Tauhidul Islam, Namhee Kim, Fernando J. Cabrera, J. N. Reddy, Ennio Tasciotti, Raffaella Righetti

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The mechanical behavior of long bones and fractures has been under investigation for many decades due to its complexity and clinical relevance. In this paper, we report a new subject-specific methodology to predict and analyze the mechanical behavior of the soft tissue at a bone interface with the intent of identifying the presence and location of bone abnormalities with high accuracy, spatial resolution, and contrast. The proposed methodology was tested on both intact and fractured rabbit femur samples with finite element-based 3-D simulations, created from actual femur computed tomography data, and ultrasound elastography experiments. The results included in this study demonstrate that elastographic strains at the bone/soft tissue interface can be used to differentiate fractured femurs from the intact ones on a distribution level. These results also demonstrate that coronal plane axial shear strain creates a unique contrast mechanism that can be used to reliably detect fractures (both complete and incomplete) in long bones. Kruskal-Wallis test further demonstrates that the contrast measure for the fracture group (simulation: 2.1286±0.2206; experiment: 2.7034 ± 1.0672) is significantly different from that for the intact group (simulation: 0 ± 0; experiment: 1.1540±0.6909) when using coronal plane axial shear strain elastography (p < 0.01). We conclude that: 1) elastography techniques can be used to accurately identify the presence and location of fractures in a long bone and 2) the proposed model-based approach can be used to predict and analyze strains at a bone fracture site and to better interpret experimental elastographic data.

Original languageEnglish (US)
Article number8395307
Pages (from-to)2704-2717
Number of pages14
JournalIEEE Transactions on Medical Imaging
Issue number12
StatePublished - Dec 2018


  • Ultrasound
  • bone imaging
  • bone/soft tissue interface
  • elastography
  • finite element analysis
  • long bone fracture
  • orthopedic biomechanics
  • orthopedics
  • shear strain
  • speckle tracking

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


Dive into the research topics of 'A model-based approach to investigate the effect of a long bone fracture on ultrasound strain elastography'. Together they form a unique fingerprint.

Cite this