A minimally invasive multimodality image-guided (MIMIG) molecular imaging system for peripheral lung cancer intervention and diagnosis

Tiancheng He, Zhong Xue, Kelvin K. Wong, Miguel Valdivia Y Alvarado, Yong Zhang, Weixin Xie, Stephen T C Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

The once-promising computed tomography (CT) lung cancer screening appears to result in high false positive rates. To tackle the common difficulties in diagnosing small lung cancer at an early stage, we developed a minimally invasive multimodality image-guided (MIMIG) interventional system for early detection and treatment of peripheral lung cancer. The system consists of new CT image segmentation for surgical planning, intervention guidance for targeting, and molecular imaging for diagnosis. Using advanced image segmentation technique the pulmonary vessels, airways, as well as nodules can be better visualized for surgical planning. These segmented results are then transformed onto the intra-procedural CT for interventional guidance using electromagnetic (EM) tracking. Diagnosis can be achieved at microscopic resolution using a fiber-optic microendoscopy. The system can also be used for fine needle aspiration biopsy to improve the accuracy and efficiency. Confirmed cancer could then be treated on-the-spot using radio-frequency ablation (RFA). The experiments on rabbits with VX2 lung cancer model show both accuracy and efficiency in localization and detecting lung cancer, as well as promising molecular imaging tumor detection.

Original languageEnglish (US)
Title of host publicationInformation Processing in Computer-Assisted Interventions - First International Conference, IPCAI 2010, Proceedings
Pages102-112
Number of pages11
DOIs
StatePublished - Dec 1 2010
Event1st International Conference on Information Processing in Computer-Assisted Interventions, IPCAI 2010 - Geneva, Switzerland
Duration: Jun 23 2010Jun 23 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6135 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Conference on Information Processing in Computer-Assisted Interventions, IPCAI 2010
CountrySwitzerland
CityGeneva
Period6/23/106/23/10

Keywords

  • Image computing
  • Image-guided intervention
  • Molecular imaging
  • Peripheral lung cancer

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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