A method for nanofluidic device prototyping using elastomeric collapse

Seung Min Park, Yun Suk Huh, Harold G. Craighead, David Erickson

Research output: Contribution to journalArticlepeer-review

147 Scopus citations


Nanofluidics represents a promising solution to problems in fields ranging from biomolecular analysis to optical property tuning. Recently a number of simple nanofluidic fabrication techniques have been introduced that exploit the deformability of elastomeric materials like polydimethylsiloxane (PDMS). These techniques are limited by the complexity of the devices that can be fabricated, which can only create straight or irregular channels normal to the direction of an applied strain. Here, we report a technique for nanofluidic fabrication based on the controlled collapse of microchannel structures. As is demonstrated, this method converts the easy to control vertical dimension of a PDMS mold to the lateral dimension of a nanochannel. We demonstrate here the creation of complex nanochannel structures as small as 60 nm and provide simple design rules for determining the conditions under which nanochannel formation will occur. The applicability of the technique to biomolecular analysis is demonstrated by showing DNA elongation in a nanochannel and a technique for optofluidic surface enhanced Raman detection of nucleic acids.

Original languageEnglish (US)
Pages (from-to)15549-15554
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number37
StatePublished - Sep 15 2009


  • Concentrator
  • Nanofluidic channel
  • Single molecule manipulation
  • Surface enhanced raman scattering

ASJC Scopus subject areas

  • General


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