A Meta-Analysis of Mesenchymal Stem Cells in Animal Models of Parkinson's Disease

Jenny Riecke, Katherine M. Johns, Chunyan Cai, Farhaan Shaheer Vahidy, Kaushik Parsha, Erin Furr-Stimming, Mya Schiess, Sean I. Savitz

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Multiple studies have been performed to evaluate the effects of mesenchymal stem cells (MSCs) in animal models of Parkinson's disease (PD). We performed a meta-analysis to estimate the treatment effect of unmodified MSCs on behavioral outcomes in preclinical studies of PD. We performed a systematic literature search to identify studies that used behavioral testing to evaluate the treatment effect of unmodified MSCs in PD models. Meta-analysis was used to determine pooled effect size for rotational behavior and limb function, and meta-regression was performed to explore sources of heterogeneity. Twenty-five studies, including three delivery routes, a wide range of doses, and multiple PD models, were examined. Significant improvement was seen in the pooled standardized mean difference (SMD) for both rotational behavior [SMD: 1.24, 95% confidence interval (95% CI): 0.84, 1.64] and limb function (SMD: 0.84, 95% CI: 0.01, 1.66). Using meta-regression, intravenous administration and higher dose had a larger effect on limb function. Treatment with MSCs improves behavioral outcomes in PD models. Our analyses suggest that MSCs could be considered for early-stage clinical trials in the treatment of PD.

Original languageEnglish (US)
Pages (from-to)2082-2090
Number of pages9
JournalStem Cells and Development
Volume24
Issue number18
DOIs
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • Hematology
  • Developmental Biology
  • Cell Biology

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