A matter of access: Nucleosome disassembly from gene promoters is the central goal of transcriptional activators

Zheng Hu; Kaifu Chen; Wei Li; Jessica K. Tyler

doi:10.4161/trns.29355

A matter of access: Nucleosome disassembly from gene promoters is the central goal of transcriptional activators

Zheng Hu, Kaifu Chen, Wei Li, Jessica K. Tyler

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

T he mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

Original language	English (US)
Article number	e29355
Journal	Transcription
Volume	5
Issue number	JUN
DOIs	https://doi.org/10.4161/trns.29355
State	Published - Jun 11 2014

Keywords

Aging
Histones
Nucleosomes
Transcription
Yeast

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.4161/trns.29355

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title = "A matter of access: Nucleosome disassembly from gene promoters is the central goal of transcriptional activators",

abstract = "T he mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.",

keywords = "Aging, Histones, Nucleosomes, Transcription, Yeast",

author = "Zheng Hu and Kaifu Chen and Wei Li and Tyler, \{Jessica K.\}",

note = "Funding Information: We are very grateful to Briana Dennehey and Candice Wike for thoughtful com ments on this manuscript. This work was supported by NIH grants RO1GM64475 and RO1CA95641 and a CPRIT rising star award to J.K.T., and CPRIT RP11047-C3, DOD W81XWH-10-1-0501 and NIH RO1HG007538 to W.L.",

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AU - Hu, Zheng

AU - Chen, Kaifu

AU - Li, Wei

AU - Tyler, Jessica K.

N1 - Funding Information: We are very grateful to Briana Dennehey and Candice Wike for thoughtful com ments on this manuscript. This work was supported by NIH grants RO1GM64475 and RO1CA95641 and a CPRIT rising star award to J.K.T., and CPRIT RP11047-C3, DOD W81XWH-10-1-0501 and NIH RO1HG007538 to W.L.

PY - 2014/6/11

Y1 - 2014/6/11

N2 - T he mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

AB - T he mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

KW - Aging

KW - Histones

KW - Nucleosomes

KW - Transcription

KW - Yeast

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JF - Transcription

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ER -

A matter of access: Nucleosome disassembly from gene promoters is the central goal of transcriptional activators

Abstract

Keywords

ASJC Scopus subject areas

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