A matter of access: Nucleosome disassembly from gene promoters is the central goal of transcriptional activators

Zheng Hu, Kaifu Chen, Wei Li, Jessica K. Tyler

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

T he mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

Original languageEnglish (US)
Article numbere29355
JournalTranscription
Volume5
Issue numberJUN
DOIs
StatePublished - Jun 11 2014

Keywords

  • Aging
  • Histones
  • Nucleosomes
  • Transcription
  • Yeast

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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