A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility

Y. Hu, X. Ma, E. A. Graviss, W. Wang, W. Jiang, B. Xu

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

This study investigated further the association between the Beijing family Mycobacterium tuberculosis circulating in rural China and anti-tuberculosis (TB) drug resistance. In total, 351 M. tuberculosis isolates were collected through a population-based epidemiological study, 223 (63.5%) of which were resistant to at least one anti-TB drug, including 53 (15.1%) multidrug-resistant (MDR) isolates. Spoligotyping found 243 isolates (69.2%) that belonged to the Beijing family. A major subgroup of the Beijing family identified by mycobacterial interspersed repetitive unit (MIRU) genotyping (223325173533), showed significantly higher frequencies of MDR (44.7% vs. 13.7%, OR 6.18, 95% CI 2.68-14.23), katG and rpoB mutations (316% vs.93%, OR 4.27, 95% CI 1.86-9.80), and being clustered by IS6110 RFLP genotyping (60.5% vs. 21.0%, OR 6.14, 95% CI 2.82-13.37) in comparison with other Beijing family isolate . Our data suggest that MIRU genotype 223325173533 of the Beijing family is associated with MDR and increased transmissibility.

Original languageEnglish (US)
Pages (from-to)130-138
Number of pages9
JournalEpidemiology and Infection
Volume139
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Beijing family
  • IS6110 restriction fragment length polymorphism
  • mycobacterial interspersed repetitive units
  • Mycobacterium tuberculosis
  • spoligotyping

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

Fingerprint Dive into the research topics of 'A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility'. Together they form a unique fingerprint.

Cite this