TY - JOUR
T1 - A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility
AU - Hu, Y.
AU - Ma, X.
AU - Graviss, E. A.
AU - Wang, W.
AU - Jiang, W.
AU - Xu, B.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - This study investigated further the association between the Beijing family Mycobacterium tuberculosis circulating in rural China and anti-tuberculosis (TB) drug resistance. In total, 351 M. tuberculosis isolates were collected through a population-based epidemiological study, 223 (63.5%) of which were resistant to at least one anti-TB drug, including 53 (15.1%) multidrug-resistant (MDR) isolates. Spoligotyping found 243 isolates (69.2%) that belonged to the Beijing family. A major subgroup of the Beijing family identified by mycobacterial interspersed repetitive unit (MIRU) genotyping (223325173533), showed significantly higher frequencies of MDR (44.7% vs. 13.7%, OR 6.18, 95% CI 2.68-14.23), katG and rpoB mutations (316% vs.93%, OR 4.27, 95% CI 1.86-9.80), and being clustered by IS6110 RFLP genotyping (60.5% vs. 21.0%, OR 6.14, 95% CI 2.82-13.37) in comparison with other Beijing family isolate . Our data suggest that MIRU genotype 223325173533 of the Beijing family is associated with MDR and increased transmissibility.
AB - This study investigated further the association between the Beijing family Mycobacterium tuberculosis circulating in rural China and anti-tuberculosis (TB) drug resistance. In total, 351 M. tuberculosis isolates were collected through a population-based epidemiological study, 223 (63.5%) of which were resistant to at least one anti-TB drug, including 53 (15.1%) multidrug-resistant (MDR) isolates. Spoligotyping found 243 isolates (69.2%) that belonged to the Beijing family. A major subgroup of the Beijing family identified by mycobacterial interspersed repetitive unit (MIRU) genotyping (223325173533), showed significantly higher frequencies of MDR (44.7% vs. 13.7%, OR 6.18, 95% CI 2.68-14.23), katG and rpoB mutations (316% vs.93%, OR 4.27, 95% CI 1.86-9.80), and being clustered by IS6110 RFLP genotyping (60.5% vs. 21.0%, OR 6.14, 95% CI 2.82-13.37) in comparison with other Beijing family isolate . Our data suggest that MIRU genotype 223325173533 of the Beijing family is associated with MDR and increased transmissibility.
KW - Beijing family
KW - IS6110 restriction fragment length polymorphism
KW - mycobacterial interspersed repetitive units
KW - Mycobacterium tuberculosis
KW - spoligotyping
UR - http://www.scopus.com/inward/record.url?scp=79952118228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952118228&partnerID=8YFLogxK
U2 - 10.1017/S0950268810000890
DO - 10.1017/S0950268810000890
M3 - Article
C2 - 20429968
AN - SCOPUS:79952118228
SN - 0950-2688
VL - 139
SP - 130
EP - 138
JO - Epidemiology and Infection
JF - Epidemiology and Infection
IS - 1
ER -