A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients

PV16000 Study Group

doi:10.1086/466532

A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients

PV16000 Study Group

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

In this study of 263 heart, kidney, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed most commonly in kidney and/or pancreas transplant patients (26%), although they were also observed, to a lesser extent, in heart (7%) and liver (4%) transplant patients. The majority of episodes of polyomavirus DNAemia were subclinical, although, in some cases, BKV DNAemia was associated with kidney rejection, and JCV DNAemia was accompanied by nonspecific symptoms. Hence, BKV and JCV DNAemia are not uncommon during the first year after kidney, heart, liver, and pancreas transplantation, and they could be associated with certain clinical syndromes in transplant patients.

Original language	English (US)
Pages (from-to)	1349-1354
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	192
Issue number	8
DOIs	https://doi.org/10.1086/466532
State	Published - Oct 15 2005

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1086/466532

Cite this

@article{399cf97e2d7e4c8fb755962995319f81,

title = "A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients",

abstract = "In this study of 263 heart, kidney, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed most commonly in kidney and/or pancreas transplant patients (26%), although they were also observed, to a lesser extent, in heart (7%) and liver (4%) transplant patients. The majority of episodes of polyomavirus DNAemia were subclinical, although, in some cases, BKV DNAemia was associated with kidney rejection, and JCV DNAemia was accompanied by nonspecific symptoms. Hence, BKV and JCV DNAemia are not uncommon during the first year after kidney, heart, liver, and pancreas transplantation, and they could be associated with certain clinical syndromes in transplant patients.",

author = "{PV16000 Study Group} and Razonable, {Raymund R.} and Brown, {Robert A.} and Atul Humar and Emma Covington and Emma Alecock and Paya, {Carlos V.} and Josie Eris and Anne Keogh and Tim Mathew and Geoff McCaughan and Kathy Nicholls and Simone Strasser and Richard Lalonde and Paul Marotta and Jutta Preiksaitis and Eric Yoshida and Iradj Gandjbakch and Yvon Lebranchu and Christophe Legendre and Faouzi Saliba and Oscar Traynor and Paolo Angeli and Francesco Menichetti and R. Gane and Ali Bakran and John Forsythe and Nigel Heaton and Peter Lodge and Derek Manas and Peter Morris and Jayan Parameshwar and Nizar Yonan and Barbara Alexander and Emily Blumberg and Brennan, {Daniel C.} and Robert Brown and Busuttil, {Ronald W.} and Ken Chavin and David Conti and Angelo DeMattos and Ed Dominguez and Eisen, {Howard J.} and Dan Fishbein and Thomas Fishbein and Robert Fisher and Richard Freeman and Chris Freise and Marquis Hart and Thomas Heffron and Richard Knight",

year = "2005",

month = oct,

day = "15",

doi = "10.1086/466532",

language = "English (US)",

volume = "192",

pages = "1349--1354",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients

AU - PV16000 Study Group

AU - Razonable, Raymund R.

AU - Brown, Robert A.

AU - Humar, Atul

AU - Covington, Emma

AU - Alecock, Emma

AU - Paya, Carlos V.

AU - Eris, Josie

AU - Keogh, Anne

AU - Mathew, Tim

AU - McCaughan, Geoff

AU - Nicholls, Kathy

AU - Strasser, Simone

AU - Lalonde, Richard

AU - Marotta, Paul

AU - Preiksaitis, Jutta

AU - Yoshida, Eric

AU - Gandjbakch, Iradj

AU - Lebranchu, Yvon

AU - Legendre, Christophe

AU - Saliba, Faouzi

AU - Traynor, Oscar

AU - Angeli, Paolo

AU - Menichetti, Francesco

AU - Gane, R.

AU - Bakran, Ali

AU - Forsythe, John

AU - Heaton, Nigel

AU - Lodge, Peter

AU - Manas, Derek

AU - Morris, Peter

AU - Parameshwar, Jayan

AU - Yonan, Nizar

AU - Alexander, Barbara

AU - Blumberg, Emily

AU - Brennan, Daniel C.

AU - Brown, Robert

AU - Busuttil, Ronald W.

AU - Chavin, Ken

AU - Conti, David

AU - DeMattos, Angelo

AU - Dominguez, Ed

AU - Eisen, Howard J.

AU - Fishbein, Dan

AU - Fishbein, Thomas

AU - Fisher, Robert

AU - Freeman, Richard

AU - Freise, Chris

AU - Hart, Marquis

AU - Heffron, Thomas

AU - Knight, Richard

PY - 2005/10/15

Y1 - 2005/10/15

N2 - In this study of 263 heart, kidney, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed most commonly in kidney and/or pancreas transplant patients (26%), although they were also observed, to a lesser extent, in heart (7%) and liver (4%) transplant patients. The majority of episodes of polyomavirus DNAemia were subclinical, although, in some cases, BKV DNAemia was associated with kidney rejection, and JCV DNAemia was accompanied by nonspecific symptoms. Hence, BKV and JCV DNAemia are not uncommon during the first year after kidney, heart, liver, and pancreas transplantation, and they could be associated with certain clinical syndromes in transplant patients.

AB - In this study of 263 heart, kidney, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed most commonly in kidney and/or pancreas transplant patients (26%), although they were also observed, to a lesser extent, in heart (7%) and liver (4%) transplant patients. The majority of episodes of polyomavirus DNAemia were subclinical, although, in some cases, BKV DNAemia was associated with kidney rejection, and JCV DNAemia was accompanied by nonspecific symptoms. Hence, BKV and JCV DNAemia are not uncommon during the first year after kidney, heart, liver, and pancreas transplantation, and they could be associated with certain clinical syndromes in transplant patients.

UR - http://www.scopus.com/inward/record.url?scp=25844526575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25844526575&partnerID=8YFLogxK

U2 - 10.1086/466532

DO - 10.1086/466532

M3 - Article

C2 - 16170751

AN - SCOPUS:25844526575

SN - 0022-1899

VL - 192

SP - 1349

EP - 1354

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 8

ER -

A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this