A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

Jose M. Munita, Truc T. Tran, Lorena Diaz, Diana Panesso, Jinnethe Reyes, Barbara E. Murray, Cesar A. Ariasa

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

Original languageEnglish (US)
Pages (from-to)2831-2833
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number6
DOIs
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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