A "leukolike" multistage delivery system to overcome biological barriers

N. Quattrocchi, C. Chiappini, L. Cooper, Mauro Ferrari, Ennio Tasciotti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The localization of theranostic nanoparticles (NPs) to a tumor site has been the subject of considerable research that so far has not translated into comparably comforting advances in clinical medicine. Due to limitations in their structure and surface properties, NPs are still unable to overcome the multiplicity of biological barriers they encounter after intravenous administration and that adversely impact their ability to reach the intended target at effective concentrations. We developed a novel hybrid biomimetic delivery system that combines together the characteristics of an artificial multistage delivery system with the physiologic components that trigger the natural ability of leukocytes (T and B cells) to transmigrate from the blood stream to the tumor site.

Original languageEnglish (US)
Title of host publicationNanotechnology 2010
Subtitle of host publicationBio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Pages346-349
Number of pages4
StatePublished - 2010
EventNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 - Anaheim, CA, United States
Duration: Jun 21 2010Jun 24 2010

Publication series

NameNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Volume3

Other

OtherNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
CountryUnited States
CityAnaheim, CA
Period6/21/106/24/10

Keywords

  • Biological barriers
  • Delivery system
  • Leukocytes
  • Nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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