A less sour sweet; blocking galectin

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

In this issue of Blood,Ouyang et al describe both an important tumor immune evasion strategy and ameans by which it can be overcome.1 They show that EBV proteins LMP1 and 2A induce expression of galectin-1 (Gal1) by the B lymphoblasts of EBV+ posttransplantation lymphoproliferative disease (PTLD), and that they could block the apoptosis this sugar-binding molecule would otherwise induce in effector cytotoxicTlymphocytes using aGal1 directed monoclonal antibody.

Original languageEnglish (US)
Pages (from-to)4165-4166
Number of pages2
JournalBlood
Volume117
Issue number16
DOIs
StatePublished - Apr 21 2011

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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