A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score

A. H. Adrogué, F. Mithani, H. N. Ibrahim, M. R. Schwartz, L. Gaber, S. A. Hebert, H. E. Adrogué

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Cytokine release storm (CRS) is a potentially fatal, hyperinflammatory condition common to both coronavirus disease 2019 (COVID-19) and reactive hemophagocytic lymphohistiocytosis (rHLH). We present our experience with the use of a diagnostic score, developed for rHLH, in a kidney transplant recipient hospitalized with COVID-19. Methods: We applied the H-Score to risk-stratify our patient to help predict his hospital course. This study was exempt from requiring specific Institutional Review Board approval, but met all the criteria required by our institution for this type of study and report including consent from the patient. Results: The calculated H-Score for our patient fell below the diagnostic cut-off value for rHLH. Because rHLH is characterized by CRS, we expected him to have a milder hospital course with COVID-19. Correlating with his below cut-off H-score, the patient had a more benign than expected hospital course. Conclusions: Because this is only a single case, we plan to retrospectively review a series of patients to validate our initial experience—that a low H-Score may correlate with a milder hospital course in kidney transplant patients with COVID-19.

Original languageEnglish (US)
Pages (from-to)2688-2692
Number of pages5
JournalTransplantation Proceedings
Volume52
Issue number9
DOIs
StatePublished - Nov 2020

Keywords

  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections/immunology
  • Cytokine Release Syndrome/diagnosis
  • Humans
  • Immunocompromised Host
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral/immunology
  • Prognosis
  • Retrospective Studies
  • SARS-CoV-2
  • Severity of Illness Index

ASJC Scopus subject areas

  • Transplantation
  • Surgery

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