A human plasma component that binds benzo(A)pyrene

Maureen McKenzie, Theodore McLemore, Patrick Rankin, R. Russell Martin, Nelda Wray, Elroy Cantrell, David Busbee

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A component capable of binding benzo(a)pyrene was measured in plasma from cigarette smokers and nonsmokers. This plasma fraction was found to have a high specificity of binding to benzo(a)pyrene, bound benzanthracene competitively with benzo(a)pyrene, and was positively correlated (r = 0.861, p < 0.001) with the capacity of the individual subject's lymphocytes to be induced for AHH activity in culture. An inverse correlation (r = 0.957, p < 0.001) between the presence of the plasma component in lung cancer patients and the capacity of lung cancer patients lymphocytes to be induced in culture is unexplained at this time. A benzo(a)pyrene-binding fraction was not found in induced or uninduced cultured lymphocytes from smokers or nonsmokers, or in homogenates of lung excisional tissue from smokers with or without primary lung cancer.

Original languageEnglish (US)
Pages (from-to)2733-2737
Number of pages5
JournalCancer
Volume42
Issue number6
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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