A hindsight reflection on the clinical studies of poly(l-glutamic acid)-paclitaxel

Jun Zhao, Eugene J. Koay, Tingting Li, Xiaoxia Wen, Chun Li

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Chemotherapy for cancer treatment is limited by the excessive toxicity to normal tissues. The design of chemodrug-loaded nanoformulations provides a unique approach to improve the treatment efficacy while minimizing toxicity. Despite the numerous publications of nanomedicine for the last several decades, however, only a small fraction of the developed nanoformulations have entered clinical trials, with even fewer being approved for clinical application. Poly(l-glutamic acid)-paclitaxel (PG-TXL) belongs to the few formulations that reached phase III clinical trials. Unfortunately, the development of PG-TXL stopped in 2016 due to the inability to show significant improvement over current standard care. This review will provide an overview of the preclinical and clinical evaluations of PG-TXL, and discuss lessons to be learned from this ordeal. The precise identification of suitable patients for clinical trial studies, deep understanding of the mechanisms of action, and an effective academic-industry partnership throughout all phases of drug development are important for the successful bench-to-bedside translation of new nanoformulations. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Biology-Inspired Nanomaterials > Peptide-Based Structures.

Original languageEnglish (US)
Article numbere1497
Pages (from-to)e1497
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume10
Issue number3
DOIs
StatePublished - May 1 2018

Keywords

  • Animals
  • Breast Neoplasms/drug therapy
  • Cell Line, Tumor
  • Clinical Trials as Topic
  • Drug Discovery
  • Drug Evaluation, Preclinical
  • Humans
  • Mice
  • Nanomedicine
  • Paclitaxel/analogs & derivatives
  • Polyglutamic Acid/analogs & derivatives
  • Research Design

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)

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