A high-throughput multi-scale assay for anti-migration compound screening by bioluminescence imaging: From in vitro to in vivo

Hong Zhao, Kemi Cui, Patrick Smollen, Stephen T. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Anti-migratory drugs constitute a promising strategy for cancer treatments. In present study, we proposed a multi-scale high-throughput anti-migratory assay by bioluminescent imaging, including in vitro 3D cell assay, in vivo anti-migratory assay on Zebrafish embryo xenograft, and mouse metastatic tumor model. The combined assay by bioluminescent imaging is less labor intensive, faster, sensitive, and easily repeatable, which make it attractive for high throughput screening for anti-migration compounds.

Original languageEnglish (US)
Title of host publication2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages120-123
Number of pages4
ISBN (Print)9781424418138
DOIs
StatePublished - Jan 1 2007
Event2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA - Bethesda, MD, United States
Duration: Nov 8 2007Nov 9 2007

Other

Other2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
CountryUnited States
CityBethesda, MD
Period11/8/0711/9/07

ASJC Scopus subject areas

  • Computer Science Applications
  • Information Systems

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