A High-Fidelity 3D Micromechanical Model of Ventricular Myocardium

David S. Li, Emilio A. Mendiola, Reza Avazmohammadi, Frank B. Sachse, Michael S. Sacks

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pulmonary arterial hypertension (PAH) imposes a pressure overload on the right ventricle (RV), leading to myofiber hypertrophy and remodeling of the extracellular collagen fiber network. While the macroscopic behavior of healthy and post-PAH RV free wall (RVFW) tissue has been studied previously, the mechanical microenvironment that drives remodeling events in the myofibers and the extracellular matrix (ECM) remains largely unexplored. We hypothesize that multiscale computational modeling of the heart, linking cellular-scale events to tissue-scale behavior, can improve our understanding of cardiac remodeling and better identify therapeutic targets. We have developed a high-fidelity microanatomically realistic model of ventricular myocardium, combining confocal microscopy techniques, soft tissue mechanics, and finite element modeling. We match our microanatomical model to the tissue-scale mechanical response of previous studies on biaxial properties of RVFW and examine the local myofiber-ECM interactions to study fiber-specific mechanics at the scale of individual myofibers. Through this approach, we determine that the interactions occurring at the tissue scale can be accounted for by accurately representing the geometry of the myofiber-collagen arrangement at the micro scale. Ultimately, models such as these can be used to link cellular-level adaptations with organ-level adaptations to lead to the development of patient-specific treatments for PAH.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 11th International Conference, FIMH 2021, Proceedings
EditorsDaniel B. Ennis, Luigi E. Perotti, Vicky Y. Wang
PublisherSpringer Science and Business Media Deutschland GmbH
Pages168-177
Number of pages10
ISBN (Print)9783030787097
DOIs
StatePublished - 2021
Event11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021 - Virtual, Online
Duration: Jun 21 2021Jun 25 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12738 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021
CityVirtual, Online
Period6/21/216/25/21

Keywords

  • Finite element modeling
  • Image based modeling
  • Soft tissue mechanics

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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