A Heterojunction Structured WO2.9-WSe2Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose

Xinghua Dong, Xinghua Dong, Ran Cheng, Ran Cheng, Shuang Zhu, Huimin Liu, Huimin Liu, Ruyi Zhou, Ruyi Zhou, Chenyang Zhang, Chenyang Zhang, Kui Chen, Kui Chen, Linqiang Mei, Linqiang Mei, Chengyan Wang, Chengyan Wang, Chunjian Su, Xiangfeng Liu, Zhanjun GuZhanjun Gu, Yuliang Zhao, Yuliang Zhao

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Radiotherapy (RT) in practical use often suffers from off-target side effects and ineffectiveness against hypoxic tumor microenvironment (TME) as well as remote metastases. With regard to these problems, herein, we provide semiconductor heterojunction structured WO2.9-WSe2-PEG nanoparticles to realize a synergistic RT/photothermal therapy (PTT)/checkpoint blockade immunotherapy (CBT) for enhanced antitumor and antimetastatic effect. Based on the heterojunction structured nanoparticle with high Z element, the nanosystem could realize non-oxygen-dependent reactive oxygen species generation by catalyzing highly expressed H2O2 in TME upon X-ray irradiation, which could further induce immunogenic cell death. Meanwhile, this nanosystem could also induce hyperthermia upon near-infrared irradiation to enhance RT outcome. With the addition of anti-PD-L1 antibody-based CBT, our results give potent evidence that local RT/PTT upon mild temperature and low radiation dose could efficiently ablate local tumors and inhibit tumor metastasis as well as prevent tumor rechallenge. Our study provides not only one kind of radiosensitizer based on semiconductor nanoparticles but also a versatile nanoplatform for simultaneous triple-combined therapy (RT/PTT/CBT) for treating both local and metastasis tumors.

Original languageEnglish (US)
Pages (from-to)5400-5416
Number of pages17
JournalACS Nano
Volume14
Issue number5
DOIs
StatePublished - May 26 2020

Keywords

  • checkpoint blockade immunotherapy
  • heterojunction structure
  • radiosensitizer
  • radiotherapy
  • WO-WSenanoparticles

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'A Heterojunction Structured WO<sub>2.9</sub>-WSe<sub>2</sub>Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose'. Together they form a unique fingerprint.

  • Cite this

    Dong, X., Dong, X., Cheng, R., Cheng, R., Zhu, S., Liu, H., Liu, H., Zhou, R., Zhou, R., Zhang, C., Zhang, C., Chen, K., Chen, K., Mei, L., Mei, L., Wang, C., Wang, C., Su, C., Liu, X., ... Zhao, Y. (2020). A Heterojunction Structured WO2.9-WSe2Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose. ACS Nano, 14(5), 5400-5416. https://doi.org/10.1021/acsnano.9b08962