A guideline on the molecular ecosystem regulating ferroptosis

Enyong Dai; Xin Chen; Andreas Linkermann; Xuejun Jiang; Rui Kang; Valerian E. Kagan; Hülya Bayir; Wan Seok Yang; Ana J. Garcia-Saez; Maria S. Ioannou; Tobias Janowitz; Qitao Ran; Wei Gu; Boyi Gan; Dmitri V. Krysko; Xiaofeng Zhu; Jiayi Wang; Stefan Krautwald; Shinya Toyokuni; Yangchun Xie; Florian R. Greten; Qing Yi; Joel Schick; Jiao Liu; Dmitry I. Gabrilovich; Jinbao Liu; Herbert J. Zeh; Donna D. Zhang; Minghua Yang; Juan Iovanna; Manfred Kopf; Timon E. Adolph; Jen Tsan Chi; Changfeng Li; Hidenori Ichijo; Michael Karin; Vijay G. Sankaran; Weiping Zou; Lorenzo Galluzzi; Ashley I. Bush; Binghui Li; Gerry Melino; Eric H. Baehrecke; Michael T. Lotze; Daniel J. Klionsky; Brent R. Stockwell; Guido Kroemer; Daolin Tang

doi:10.1038/s41556-024-01360-8

A guideline on the molecular ecosystem regulating ferroptosis

Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayir, Wan Seok Yang, Ana J. Garcia-Saez, Maria S. Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V. Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun XieFlorian R. Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I. Gabrilovich, Jinbao Liu, Herbert J. Zeh, Donna D. Zhang, Minghua Yang, Juan Iovanna, Manfred Kopf, Timon E. Adolph, Jen Tsan Chi, Changfeng Li, Hidenori Ichijo, Michael Karin, Vijay G. Sankaran, Weiping Zou, Lorenzo Galluzzi, Ashley I. Bush, Binghui Li, Gerry Melino, Eric H. Baehrecke, Michael T. Lotze, Daniel J. Klionsky, Brent R. Stockwell, Guido Kroemer, Daolin Tang

Research output: Contribution to journal › Review article › peer-review

199 Scopus citations

Abstract

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

Original language	English (US)
Pages (from-to)	1447-1457
Number of pages	11
Journal	Nature Cell Biology
Volume	26
Issue number	9
DOIs	https://doi.org/10.1038/s41556-024-01360-8
State	Published - Sep 2024

Keywords

Ferroptosis/genetics
Humans
Animals
Lipid Peroxidation
Signal Transduction
Reactive Oxygen Species/metabolism
Iron/metabolism

ASJC Scopus subject areas

Cell Biology

Divisions

Medical Oncology

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10.1038/s41556-024-01360-8

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Dai, E., Chen, X., Linkermann, A., Jiang, X., Kang, R., Kagan, V. E., Bayir, H., Yang, W. S., Garcia-Saez, A. J., Ioannou, M. S., Janowitz, T., Ran, Q., Gu, W., Gan, B., Krysko, D. V., Zhu, X., Wang, J., Krautwald, S., Toyokuni, S., ... Tang, D. (2024). A guideline on the molecular ecosystem regulating ferroptosis. Nature Cell Biology, 26(9), 1447-1457. https://doi.org/10.1038/s41556-024-01360-8

Dai, E, Chen, X, Linkermann, A, Jiang, X, Kang, R, Kagan, VE, Bayir, H, Yang, WS, Garcia-Saez, AJ, Ioannou, MS, Janowitz, T, Ran, Q, Gu, W, Gan, B, Krysko, DV, Zhu, X, Wang, J, Krautwald, S, Toyokuni, S, Xie, Y, Greten, FR, Yi, Q, Schick, J, Liu, J, Gabrilovich, DI, Liu, J, Zeh, HJ, Zhang, DD, Yang, M, Iovanna, J, Kopf, M, Adolph, TE, Chi, JT, Li, C, Ichijo, H, Karin, M, Sankaran, VG, Zou, W, Galluzzi, L, Bush, AI, Li, B, Melino, G, Baehrecke, EH, Lotze, MT, Klionsky, DJ, Stockwell, BR, Kroemer, G & Tang, D 2024, 'A guideline on the molecular ecosystem regulating ferroptosis', Nature Cell Biology, vol. 26, no. 9, pp. 1447-1457. https://doi.org/10.1038/s41556-024-01360-8

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title = "A guideline on the molecular ecosystem regulating ferroptosis",

abstract = "Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.",

keywords = "Ferroptosis/genetics, Humans, Animals, Lipid Peroxidation, Signal Transduction, Reactive Oxygen Species/metabolism, Iron/metabolism",

author = "Enyong Dai and Xin Chen and Andreas Linkermann and Xuejun Jiang and Rui Kang and Kagan, \{Valerian E.\} and H{\"u}lya Bayir and Yang, \{Wan Seok\} and Garcia-Saez, \{Ana J.\} and Ioannou, \{Maria S.\} and Tobias Janowitz and Qitao Ran and Wei Gu and Boyi Gan and Krysko, \{Dmitri V.\} and Xiaofeng Zhu and Jiayi Wang and Stefan Krautwald and Shinya Toyokuni and Yangchun Xie and Greten, \{Florian R.\} and Qing Yi and Joel Schick and Jiao Liu and Gabrilovich, \{Dmitry I.\} and Jinbao Liu and Zeh, \{Herbert J.\} and Zhang, \{Donna D.\} and Minghua Yang and Juan Iovanna and Manfred Kopf and Adolph, \{Timon E.\} and Chi, \{Jen Tsan\} and Changfeng Li and Hidenori Ichijo and Michael Karin and Sankaran, \{Vijay G.\} and Weiping Zou and Lorenzo Galluzzi and Bush, \{Ashley I.\} and Binghui Li and Gerry Melino and Baehrecke, \{Eric H.\} and Lotze, \{Michael T.\} and Klionsky, \{Daniel J.\} and Stockwell, \{Brent R.\} and Guido Kroemer and Daolin Tang",

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doi = "10.1038/s41556-024-01360-8",

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AU - Linkermann, Andreas

AU - Jiang, Xuejun

AU - Kang, Rui

AU - Kagan, Valerian E.

AU - Bayir, Hülya

AU - Yang, Wan Seok

AU - Garcia-Saez, Ana J.

AU - Ioannou, Maria S.

AU - Janowitz, Tobias

AU - Ran, Qitao

AU - Gu, Wei

AU - Gan, Boyi

AU - Krysko, Dmitri V.

AU - Zhu, Xiaofeng

AU - Wang, Jiayi

AU - Krautwald, Stefan

AU - Toyokuni, Shinya

AU - Xie, Yangchun

AU - Greten, Florian R.

AU - Yi, Qing

AU - Schick, Joel

AU - Liu, Jiao

AU - Gabrilovich, Dmitry I.

AU - Liu, Jinbao

AU - Zeh, Herbert J.

AU - Zhang, Donna D.

AU - Yang, Minghua

AU - Iovanna, Juan

AU - Kopf, Manfred

AU - Adolph, Timon E.

AU - Chi, Jen Tsan

AU - Li, Changfeng

AU - Ichijo, Hidenori

AU - Karin, Michael

AU - Sankaran, Vijay G.

AU - Zou, Weiping

AU - Galluzzi, Lorenzo

AU - Bush, Ashley I.

AU - Li, Binghui

AU - Melino, Gerry

AU - Baehrecke, Eric H.

AU - Lotze, Michael T.

AU - Klionsky, Daniel J.

AU - Stockwell, Brent R.

AU - Kroemer, Guido

AU - Tang, Daolin

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AB - Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

KW - Ferroptosis/genetics

KW - Humans

KW - Animals

KW - Lipid Peroxidation

KW - Signal Transduction

KW - Reactive Oxygen Species/metabolism

KW - Iron/metabolism

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AN - SCOPUS:85186233911

SN - 1465-7392

VL - 26

SP - 1447

EP - 1457

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 9

ER -

A guideline on the molecular ecosystem regulating ferroptosis

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Keywords

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