A guideline on the molecular ecosystem regulating ferroptosis

Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayir, Wan Seok Yang, Ana J. Garcia-Saez, Maria S. Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V. Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun XieFlorian R. Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I. Gabrilovich, Jinbao Liu, Herbert J. Zeh, Donna D. Zhang, Minghua Yang, Juan Iovanna, Manfred Kopf, Timon E. Adolph, Jen Tsan Chi, Changfeng Li, Hidenori Ichijo, Michael Karin, Vijay G. Sankaran, Weiping Zou, Lorenzo Galluzzi, Ashley I. Bush, Binghui Li, Gerry Melino, Eric H. Baehrecke, Michael T. Lotze, Daniel J. Klionsky, Brent R. Stockwell, Guido Kroemer, Daolin Tang

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

Original languageEnglish (US)
JournalNature Cell Biology
DOIs
StateAccepted/In press - 2024

ASJC Scopus subject areas

  • Cell Biology

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