@article{7e84d50901cf441bb760a3e6fbeec8b4,
title = "A Graphdiyne Oxide-Based Iron Sponge with Photothermally Enhanced Tumor-Specific Fenton Chemistry",
abstract = "Fenton reaction-mediated oncotherapy is an emerging strategy which uses iron ions to catalytically convert endogenous hydrogen peroxide into hydroxyl radicals, the most reactive oxygen species found in biology, for efficient cancer therapy. However, Fenton reaction efficiency in tumor tissue is typically limited due to restrictive conditions. One strategy to overcome this obstacle is to increase the temperature specifically at the tumor site. Herein, a tumor-targeting iron sponge (TTIS) nanocomposite based on graphdiyne oxide, which has a high affinity for iron is described. TTIS can accumulate in tumor tissue by decoration with a tumor-targeting polymer to enable tumor photoacoustic and magnetic resonance imaging. With its excellent photothermal conversion efficiency (37.5%), TTIS is an efficient photothermal therapy (PTT) agent. Moreover, the heat produced in the process of PTT can accelerate the release of iron ions from TTIS and simultaneously enhance the efficiency of the Fenton reaction, thus achieving a combined PTT and Fenton reaction-mediated cancer therapy. This work introduces a graphdiyne oxide-based iron sponge that exerts an enhanced antitumor effect through PTT and Fenton chemistry.",
keywords = "fenton reaction, graphdiyne oxide, iron sponge, photothermal therapy",
author = "Huan Min and Yingqiu Qi and Yinlong Zhang and Xuexiang Han and Keman Cheng and Ying Liu and Huibiao Liu and Jianshe Hu and Guangjun Nie and Yiye Li",
note = "Funding Information: This work was supported by grants from the National Key R&D Program of China (No. 2018YFA0208900), the Strategic Priority Research Program of Chinese Academy of Sciences (No. XDB36000000), the National Natural Science Foundation of China (Nos. 91543127 and 51573191), and the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS, China Postdoctoral Science Foundation (Nos. 2019TQ0285 and 2019M662513). The authors are grateful to Dr. Yuqing Wang at the National Center for Nanoscience and Technology for MRI experiments. Funding Information: This work was supported by grants from the National Key R&D Program of China (No. 2018YFA0208900), the Strategic Priority Research Program of Chinese Academy of Sciences (No. XDB36000000), the National Natural Science Foundation of China (Nos. 91543127 and 51573191), and the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS, China Postdoctoral Science Foundation (Nos. 2019TQ0285 and 2019M662513). The authors are grateful to Dr. Yuqing Wang at the National Center for Nanoscience and Technology for MRI experiments. Note: The spelling of the author name Huibiao Liu was corrected on August 4, 2020, after initial publication online. Publisher Copyright: {\textcopyright} 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = aug,
day = "1",
doi = "10.1002/adma.202000038",
language = "English (US)",
volume = "32",
pages = "e2000038",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley",
number = "31",
}