A graded multifunctional hybrid scaffold with superparamagnetic ability for periodontal regeneration

Simone Sprio, Elisabetta Campodoni, Monica Sandri, Lorenzo Preti, Tobias Keppler, Frank A. Müller, Nicola M. Pugno, Anna Tampieri

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different mineralized and non-mineralized dental tissues. In this respect, the present work develops a novel multifunctional hybrid scaffold recapitulating the different features of alveolar bone, periodontal ligament, and cementum by integrating the biomineralization process, and tape casting and electrospinning techniques. The scaffold is endowed with a superparamagnetic ability, thanks to the use of a biocompatible, bioactive superparamagnetic apatite phase, as a mineral component that is able to promote osteogenesis and to be activated by remote magnetic signals. The periodontal scaffold was obtained by engineering three different layers, recapitulating the relevant compositional and microstructural features of the target tissues, into a monolithic multifunctional graded device. Physico-chemical, morphological, and ultrastructural analyses, in association with preliminary in vitro investigations carried out with mesenchymal stem cells, confirm that the final scaffold exhibits a good mimicry of the periodontal tissue complex, with excellent cytocompatibility and cell viability, making it very promising for regenerative applications in dentistry.

Original languageEnglish (US)
Article number3604
JournalInternational journal of molecular sciences
Volume19
Issue number11
DOIs
StatePublished - 2018

Keywords

  • Biomimetic hybrid scaffold
  • Biomineralization
  • Collagen
  • Electrospinning
  • Periodontal regeneration
  • Superparamagnetic hydroxyapatite

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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