@inproceedings{7b842eaaf4954f6fbaf94eb2569a8b92,
title = "A framework for informing segmentation of in vivo MRI with information derived from ex vivo imaging: Application in the medial temporal lobe",
abstract = "Automatic segmentation of cortical and subcortical structures is commonplace in brain MRI literature and is frequently used as the first step towards quantitative analysis of structural and functional neuroimaging. Most approaches to brain structure segmentation are based on propagation of anatomical information from example MRI datasets, called atlases or templates, that are manually labeled by experts. The accuracy of automatic segmentation is usually validated against the 'bronze' standard of manual segmentation of test MRI datasets. However, good performance vis-a-vis manual segmentation does not imply accuracy relative to the underlying true anatomical boundaries. In the context of segmentation of hippocampal subfields and functionally related medial temporal lobe cortical subregions, we explore the challenges associated with validating existing automatic segmentation techniques against underlying histologically-derived anatomical 'gold' standard; and, further, developing automatic in vivo MRI segmentation techniques informed by histological imaging.",
author = "Yushkevich, {Paul A.} and Laura Wisse and Daniel Adler and Ranjit Ittyerah and Pluta, {John B.} and Robinson, {John L.} and Theresa Schuck and Trojanowski, {John Q.} and Murray Grossman and Detre, {John A.} and Elliott, {Mark A.} and Toledo, {Jon B.} and Weixia Liu and Stephen Pickup and Das, {Sandhitsu R.} and Wolk, {David A.}",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 ; Conference date: 16-08-2016 Through 20-08-2016",
year = "2016",
month = oct,
day = "13",
doi = "10.1109/EMBC.2016.7592099",
language = "English (US)",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "6014--6017",
booktitle = "2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016",
address = "United States",
}