Abstract
Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated a systems biology investigative strategy designed to enhance and accelerate our understanding of disease processes. Here, we provide examples of the progress made by exploiting an integrated genome-wide research platform to gain new insight into molecular pathogenesis. The studies have provided many new avenues for basic and translational research.
Original language | English (US) |
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Pages (from-to) | 2455-2463 |
Number of pages | 9 |
Journal | Journal of Clinical Investigation |
Volume | 119 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2009 |
ASJC Scopus subject areas
- Medicine(all)