A Critical Appraisal of Lipid Management in the Post-Statin Era: Comparison on Guidelines, Therapeutic Targets, and Screening in a Case-Based Framework of Lipid Management

Jared Spitz; Jaideep Patel; Anandita Agarwala; Garima Sharma; Anurag Mehta; Pradeep Natarajan; Khurram Nasir; Pamela Morris; Roger S. Blumenthal; Michael D. Shapiro

doi:10.1016/j.jacadv.2025.101823

A Critical Appraisal of Lipid Management in the Post-Statin Era: Comparison on Guidelines, Therapeutic Targets, and Screening in a Case-Based Framework of Lipid Management

Jared Spitz, Jaideep Patel, Anandita Agarwala, Garima Sharma, Anurag Mehta, Pradeep Natarajan, Khurram Nasir, Pamela Morris, Roger S. Blumenthal, Michael D. Shapiro

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The role of low-density lipoprotein-cholesterol in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD) is well established. Lipid management remains the cornerstone of addressing ASCVD. In addition to statin therapy, there is a large and growing number of nonstatin therapies available to manage elevated cholesterol levels. This expert panel seeks to review current international recommendations regarding lipid management. In addition, complex yet commonly encountered lipid-management cases are provided. Guidance on applying guideline-based recommendations as well as newer evidence to the evaluation and management of ASCVD-risk lipid management is then provided.

Original language	English (US)
Article number	101823
Journal	JACC: Advances
Volume	4
Issue number	6P2
DOIs	https://doi.org/10.1016/j.jacadv.2025.101823
State	Published - Jun 2025

Keywords

atherosclerotic cardiovascular disease
cholesterol
lipids
pharmacotherapy
prevention
statins
triglycerides

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacadv.2025.101823

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Spitz, J., Patel, J., Agarwala, A., Sharma, G., Mehta, A., Natarajan, P., Nasir, K., Morris, P., Blumenthal, R. S., & Shapiro, M. D. (2025). A Critical Appraisal of Lipid Management in the Post-Statin Era: Comparison on Guidelines, Therapeutic Targets, and Screening in a Case-Based Framework of Lipid Management. JACC: Advances, 4(6P2), Article 101823. https://doi.org/10.1016/j.jacadv.2025.101823

Spitz, J, Patel, J, Agarwala, A, Sharma, G, Mehta, A, Natarajan, P, Nasir, K, Morris, P, Blumenthal, RS & Shapiro, MD 2025, 'A Critical Appraisal of Lipid Management in the Post-Statin Era: Comparison on Guidelines, Therapeutic Targets, and Screening in a Case-Based Framework of Lipid Management', JACC: Advances, vol. 4, no. 6P2, 101823. https://doi.org/10.1016/j.jacadv.2025.101823

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abstract = "The role of low-density lipoprotein-cholesterol in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD) is well established. Lipid management remains the cornerstone of addressing ASCVD. In addition to statin therapy, there is a large and growing number of nonstatin therapies available to manage elevated cholesterol levels. This expert panel seeks to review current international recommendations regarding lipid management. In addition, complex yet commonly encountered lipid-management cases are provided. Guidance on applying guideline-based recommendations as well as newer evidence to the evaluation and management of ASCVD-risk lipid management is then provided.",

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AU - Natarajan, Pradeep

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A Critical Appraisal of Lipid Management in the Post-Statin Era: Comparison on Guidelines, Therapeutic Targets, and Screening in a Case-Based Framework of Lipid Management

Abstract

Keywords

ASJC Scopus subject areas

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