A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides

Bianca F. Bonini; Mauro Comes-Franchini; Mariafrancesca Fochi; Germana Mazzanti; Alfredo Ricci; Greta Varchi

doi:10.1055/s-1998-1831

A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides

Bianca F. Bonini, Mauro Comes-Franchini, Mariafrancesca Fochi, Germana Mazzanti, Alfredo Ricci, Greta Varchi

Houston Methodist

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.

Original language	English (US)
Pages (from-to)	1013-1015
Number of pages	3
Journal	Synlett
Issue number	9
DOIs	https://doi.org/10.1055/s-1998-1831
State	Published - Sep 1998

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-1998-1831

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abstract = "Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.",

author = "Bonini, \{Bianca F.\} and Mauro Comes-Franchini and Mariafrancesca Fochi and Germana Mazzanti and Alfredo Ricci and Greta Varchi",

year = "1998",

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doi = "10.1055/s-1998-1831",

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T1 - A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides

AU - Bonini, Bianca F.

AU - Comes-Franchini, Mauro

AU - Fochi, Mariafrancesca

AU - Mazzanti, Germana

AU - Ricci, Alfredo

AU - Varchi, Greta

PY - 1998/9

Y1 - 1998/9

N2 - Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.

AB - Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.

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U2 - 10.1055/s-1998-1831

DO - 10.1055/s-1998-1831

M3 - Article

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JO - Synlett

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ER -

A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides

Abstract

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