A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides

Bianca F. Bonini, Mauro Comes-Franchini, Mariafrancesca Fochi, Germana Mazzanti, Alfredo Ricci, Greta Varchi

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.

Original languageEnglish (US)
Pages (from-to)1013-1015
Number of pages3
JournalSynlett
Issue number9
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Organic Chemistry

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