A conceptually new type of bio-hybrid scaffold for bone regeneration

A. Tampieri, E. Landi, F. Valentini, M. Sandri, T. D'Alessandro, V. Dediu, M. Marcacci

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Magnetic bio-hybrid porous scaffolds have been synthesized, nucleating nano-apatite in situ on self-assembling collagen, in the presence of magnetite nano-particles. The magnetic phase acted as a sort of cross-linking agent for the collagen, inducing a chemico-physical-mechanical stabilization of the material and allowing us to control the porosity network of the scaffold. Gradients of bio-mineralization and magnetization were also developed for osteochondral application. The good potentiality of the material as a biomedical device, able to offer assistance to bone regeneration through scaffold reloading with specific factors guided by an external magnetic field, has been preliminarily investigated. Up to now the proof of this concept has been realized through in vitro assessments.

Original languageEnglish (US)
Article number015104
JournalNanotechnology
Volume22
Issue number1
DOIs
StatePublished - Jan 7 2011

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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