A computational model for drug release from PLGA implant

Miljan Milosevic, Dusica Stojanovic, Vladimir Simic, Bogdan Milicevic, Andjela Radisavljevic, Petar Uskokovic, Milos Kojic

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Due to the relative ease of producing nanofibers with a core-shell structure, emulsion electrospinning has been investigated intensively in making nanofibrous drug delivery systems for controlled and sustained release. Predictions of drug release rates from the poly (D,L-lactic-co-glycolic acid) (PLGA) produced via emulsion electrospinning can be a very difficult task due to the complexity of the system. A computational finite element methodology was used to calculate the diffusion mass transport of Rhodamine B (fluorescent drug model). Degradation effects and hydrophobicity (partitioning phenomenon) at the fiber/surrounding interface were included in the models. The results are validated by experiments where electrospun PLGA nanofiber mats with different contents were used. A new approach to three-dimensional (3D) modeling of nanofibers is presented in this work. The authors have introduced two original models for diffusive drug release from nanofibers to the 3D surrounding medium discretized by continuum 3D finite elements: (1) A model with simple radial one-dimensional (1D) finite elements, and (2) a model consisting of composite smeared finite elements (CSFEs). Numerical solutions, compared to experiments, demonstrate that both computational models provide accurate predictions of the diffusion process and can therefore serve as efficient tools for describing transport inside a polymer fiber network and drug release to the surrounding porous medium.

Original languageEnglish (US)
Article number2416
JournalMaterials
Volume11
Issue number12
DOIs
StatePublished - Nov 29 2018

Keywords

  • Composite smeared finite element
  • Computational modeling
  • Controlled drug release
  • Diffusion
  • Emulsion electrospinning
  • Radial finite element

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'A computational model for drug release from PLGA implant'. Together they form a unique fingerprint.

Cite this