TY - JOUR
T1 - A comprehensive overview of metaplastic breast cancer
T2 - clinical features and molecular aberrations
AU - Reddy, Tejaswini P.
AU - Rosato, Roberto R.
AU - Li, Xiaoxian
AU - Moulder, Stacy
AU - Piwnica-Worms, Helen
AU - Chang, Jenny C.
N1 - Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/11/4
Y1 - 2020/11/4
N2 - Metaplastic breast cancer (MpBC) is an exceedingly rare breast cancer variant that is therapeutically challenging and aggressive. MpBC is defined by the histological presence of at least two cellular types, typically epithelial and mesenchymal components. This variant harbors a triple-negative breast cancer (TNBC) phenotype, yet has a worse prognosis and decreased survival compared to TNBC. There are currently no standardized treatment guidelines specifically for MpBC. However, prior studies have found that MpBC typically has molecular alterations in epithelial-to-mesenchymal transition, amplification of epidermal growth factor receptor, PI3K/Akt signaling, nitric oxide signaling, Wnt/β-catenin signaling, altered immune response, and cell cycle dysregulation. Some of these molecular alterations have been studied as therapeutic targets, in both the preclinical and clinical setting. This current review discusses the histological organization and cellular origins of MpBC, molecular alterations, the role of radiation therapy, and current clinical trials for MpBC.
AB - Metaplastic breast cancer (MpBC) is an exceedingly rare breast cancer variant that is therapeutically challenging and aggressive. MpBC is defined by the histological presence of at least two cellular types, typically epithelial and mesenchymal components. This variant harbors a triple-negative breast cancer (TNBC) phenotype, yet has a worse prognosis and decreased survival compared to TNBC. There are currently no standardized treatment guidelines specifically for MpBC. However, prior studies have found that MpBC typically has molecular alterations in epithelial-to-mesenchymal transition, amplification of epidermal growth factor receptor, PI3K/Akt signaling, nitric oxide signaling, Wnt/β-catenin signaling, altered immune response, and cell cycle dysregulation. Some of these molecular alterations have been studied as therapeutic targets, in both the preclinical and clinical setting. This current review discusses the histological organization and cellular origins of MpBC, molecular alterations, the role of radiation therapy, and current clinical trials for MpBC.
KW - Epithelial-to-mesenchymal transition
KW - Metaplastic breast cancer
KW - NOS signaling
KW - PI3K signaling
KW - Genes, Neoplasm/genetics
KW - Humans
KW - Phosphatidylinositol 3-Kinases/metabolism
KW - Nitric Oxide Synthase/metabolism
KW - Metaplasia/genetics
KW - Epithelial-Mesenchymal Transition
KW - Cell Line, Tumor
KW - Female
KW - Breast Neoplasms/genetics
KW - Molecular Targeted Therapy/methods
KW - Wnt Signaling Pathway
KW - Triple Negative Breast Neoplasms/genetics
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U2 - 10.1186/s13058-020-01353-z
DO - 10.1186/s13058-020-01353-z
M3 - Review article
C2 - 33148288
AN - SCOPUS:85094951195
VL - 22
JO - Breast Cancer Research
JF - Breast Cancer Research
SN - 1465-5411
IS - 1
M1 - 121
ER -