A comprehensive genetic map of the mouse genome

William F. Dietrich, Joyce Miller, Robert Steen, Mark A. Merchant, Deborah Damron-Boles, Zeeshan Husain, Robert Dredge, Mark J. Daly, Kimberly A. Ingalls, Tara J. O'Connor, Cheryl A. Evans, Margaret M. DeAngelis, David M. Levinson, Leonid Kruglyak, Nathan Goodman, Neal G. Copeland, Nancy A. Jenkins, Trevor L. Hawkins, Lincoln Stein, David C. PageEric S. Lander

Research output: Contribution to journalArticlepeer-review

742 Scopus citations

Abstract

The availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons. We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse. Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalNature
Volume380
Issue number6570
DOIs
StatePublished - Mar 14 1996

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'A comprehensive genetic map of the mouse genome'. Together they form a unique fingerprint.

Cite this