A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography

Raksha Raghunathan; Chih Hao Liu; Manmohan Singh; Rajesh C. Miranda; Kirill V. Larin

doi:10.1117/12.2583340

A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography

Raksha Raghunathan, Chih Hao Liu, Manmohan Singh, Rajesh C. Miranda, Kirill V. Larin

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Prenatal alcohol exposure (PAE) causes a spectrum of abnormalities, collectively termed as fetal alcohol spectrum disorders (FASD). The severity of the defect depends on the amount of alcohol consumed and the period of gestation during which alcohol was consumed. PAE during the second trimester is known to affect fetal brain development as this period of gestation marks the peak period for fetal neurogenesis and angiogenesis. Our previous study evaluated acute changes in fetal brain vasculature after PAE. However, not much has been done to assess concurrent changes on both the fetal and maternal side. This study uses correlation mapping optical coherence angiography (cm-OCA) to evaluate changes in vasculature in the fetal brain and the maternal hindlimb after maternal exposure to alcohol. Results showed drastic vasoconstriction in the fetal brain while vasodilation was seen in the mother, unlike results from the sham group, where there was no significant change in both the fetus and the mother. Changes seen in the fetal brain was similar to our previously published results.

Original language	English (US)
Title of host publication	Dynamics and Fluctuations in Biomedical Photonics XVIII
Editors	Valery V. Tuchin, Martin J. Leahy, Ruikang K. Wang
Publisher	SPIE
ISBN (Electronic)	9781510641174
DOIs	https://doi.org/10.1117/12.2583340
State	Published - 2021
Event	Dynamics and Fluctuations in Biomedical Photonics XVIII 2021 - Virtual, Online, United States Duration: Mar 6 2021 → Mar 11 2021

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11641
ISSN (Print)	1605-7422

Conference

Conference	Dynamics and Fluctuations in Biomedical Photonics XVIII 2021
Country/Territory	United States
City	Virtual, Online
Period	3/6/21 → 3/11/21

Keywords

Brain vasculature
Ethanol
Maternal hindlimb
Murine embryos
Optical coherence tomography

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2583340

Cite this

Raghunathan, R., Liu, C. H., Singh, M., Miranda, R. C., & Larin, K. V. (2021). A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography. In V. V. Tuchin, M. J. Leahy, & R. K. Wang (Eds.), Dynamics and Fluctuations in Biomedical Photonics XVIII Article 1164109 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11641). SPIE. https://doi.org/10.1117/12.2583340

A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography. / Raghunathan, Raksha; Liu, Chih Hao; Singh, Manmohan et al.
Dynamics and Fluctuations in Biomedical Photonics XVIII. ed. / Valery V. Tuchin; Martin J. Leahy; Ruikang K. Wang. SPIE, 2021. 1164109 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11641).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Raghunathan, R, Liu, CH, Singh, M, Miranda, RC & Larin, KV 2021, A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography. in VV Tuchin, MJ Leahy & RK Wang (eds), Dynamics and Fluctuations in Biomedical Photonics XVIII., 1164109, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11641, SPIE, Dynamics and Fluctuations in Biomedical Photonics XVIII 2021, Virtual, Online, United States, 3/6/21. https://doi.org/10.1117/12.2583340

Raghunathan R, Liu CH, Singh M, Miranda RC, Larin KV. A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography. In Tuchin VV, Leahy MJ, Wang RK, editors, Dynamics and Fluctuations in Biomedical Photonics XVIII. SPIE. 2021. 1164109. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2583340

Raghunathan, Raksha ; Liu, Chih Hao ; Singh, Manmohan et al. / A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography. Dynamics and Fluctuations in Biomedical Photonics XVIII. editor / Valery V. Tuchin ; Martin J. Leahy ; Ruikang K. Wang. SPIE, 2021. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "Prenatal alcohol exposure (PAE) causes a spectrum of abnormalities, collectively termed as fetal alcohol spectrum disorders (FASD). The severity of the defect depends on the amount of alcohol consumed and the period of gestation during which alcohol was consumed. PAE during the second trimester is known to affect fetal brain development as this period of gestation marks the peak period for fetal neurogenesis and angiogenesis. Our previous study evaluated acute changes in fetal brain vasculature after PAE. However, not much has been done to assess concurrent changes on both the fetal and maternal side. This study uses correlation mapping optical coherence angiography (cm-OCA) to evaluate changes in vasculature in the fetal brain and the maternal hindlimb after maternal exposure to alcohol. Results showed drastic vasoconstriction in the fetal brain while vasodilation was seen in the mother, unlike results from the sham group, where there was no significant change in both the fetus and the mother. Changes seen in the fetal brain was similar to our previously published results.",

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AU - Miranda, Rajesh C.

AU - Larin, Kirill V.

PY - 2021

Y1 - 2021

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AB - Prenatal alcohol exposure (PAE) causes a spectrum of abnormalities, collectively termed as fetal alcohol spectrum disorders (FASD). The severity of the defect depends on the amount of alcohol consumed and the period of gestation during which alcohol was consumed. PAE during the second trimester is known to affect fetal brain development as this period of gestation marks the peak period for fetal neurogenesis and angiogenesis. Our previous study evaluated acute changes in fetal brain vasculature after PAE. However, not much has been done to assess concurrent changes on both the fetal and maternal side. This study uses correlation mapping optical coherence angiography (cm-OCA) to evaluate changes in vasculature in the fetal brain and the maternal hindlimb after maternal exposure to alcohol. Results showed drastic vasoconstriction in the fetal brain while vasodilation was seen in the mother, unlike results from the sham group, where there was no significant change in both the fetus and the mother. Changes seen in the fetal brain was similar to our previously published results.

KW - Brain vasculature

KW - Ethanol

KW - Maternal hindlimb

KW - Murine embryos

KW - Optical coherence tomography

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A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography

Abstract

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Keywords

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