TY - JOUR
T1 - A comparison of anticonvulsants in the treatment of impulsive aggression
AU - Stanford, Matthew S.
AU - Helfritz, Laura E.
AU - Conklin, Sarah M.
AU - Villemarette-Pittman, Nicole R.
AU - Greve, Kevin W.
AU - Adams, Donald
AU - Houston, Rebecca J.
PY - 2005/2/1
Y1 - 2005/2/1
N2 - This study compared the behavioral effects of 3 anticonvulsants in impulsive aggressive men. In a double-blind, placebo-controlled, parallel groups design, participants were randomly assigned to 1 of 4 6-week treatments: phenytoin (n = 7), carbamazepine (n = 7), valproate (n = 7), or placebo (n = 8). The efficacy measure was the average aggression score, a global severity index from the Overt Aggression Scale (J. M. Silver & S. C. Yudofsky, 1991). Analysis showed a significant reduction in impulsive aggression during all 3 anticonvulsant conditions compared with placebo. However, the treatment effect during carbamazepine administration was slightly delayed compared with phenytoin and valproate. These findings suggest that increased use of anticonvulsants could make a significant impact in the control of impulsive aggression in both mental health and criminal justice settings.
AB - This study compared the behavioral effects of 3 anticonvulsants in impulsive aggressive men. In a double-blind, placebo-controlled, parallel groups design, participants were randomly assigned to 1 of 4 6-week treatments: phenytoin (n = 7), carbamazepine (n = 7), valproate (n = 7), or placebo (n = 8). The efficacy measure was the average aggression score, a global severity index from the Overt Aggression Scale (J. M. Silver & S. C. Yudofsky, 1991). Analysis showed a significant reduction in impulsive aggression during all 3 anticonvulsant conditions compared with placebo. However, the treatment effect during carbamazepine administration was slightly delayed compared with phenytoin and valproate. These findings suggest that increased use of anticonvulsants could make a significant impact in the control of impulsive aggression in both mental health and criminal justice settings.
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U2 - 10.1037/1064-1297.13.1.72
DO - 10.1037/1064-1297.13.1.72
M3 - Article
C2 - 15727506
AN - SCOPUS:13844320622
SN - 1064-1297
VL - 13
SP - 72
EP - 77
JO - Experimental and Clinical Psychopharmacology
JF - Experimental and Clinical Psychopharmacology
IS - 1
ER -