A comparative study of short- and long-TE 1H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors

Changho Choi; Sandeep Ganji; Keith Hulsey; Akshay Madan; Zoltan Kovacs; Ivan Dimitrov; Song Zhang; Kumar Pichumani; Dianne Mendelsohn; Bruce Mickey; Craig Malloy; Robert Bachoo; Ralph Deberardinis; Elizabeth Maher

doi:10.1002/nbm.2943

A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors

Changho Choi, Sandeep Ganji, Keith Hulsey, Akshay Madan, Zoltan Kovacs, Ivan Dimitrov, Song Zhang, Kumar Pichumani, Dianne Mendelsohn, Bruce Mickey, Craig Malloy, Robert Bachoo, Ralph Deberardinis, Elizabeth Maher

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The ¹H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

Original language	English (US)
Pages (from-to)	1242-1250
Number of pages	9
Journal	NMR in Biomedicine
Volume	26
Issue number	10
DOIs	https://doi.org/10.1002/nbm.2943
State	Published - Oct 2013

Keywords

2-hydroxyglutarate (2HG)
3 T
H MRS
Human brain
IDH-mutated gliomas
Point-resolved spectroscopy (PRESS)
Short/long TE
Volume-localized simulations

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Spectroscopy

Access to Document

10.1002/nbm.2943

Cite this

Choi, C., Ganji, S., Hulsey, K., Madan, A., Kovacs, Z., Dimitrov, I., Zhang, S., Pichumani, K., Mendelsohn, D., Mickey, B., Malloy, C., Bachoo, R., Deberardinis, R., & Maher, E. (2013). A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors. NMR in Biomedicine, 26(10), 1242-1250. https://doi.org/10.1002/nbm.2943

Choi, C, Ganji, S, Hulsey, K, Madan, A, Kovacs, Z, Dimitrov, I, Zhang, S, Pichumani, K, Mendelsohn, D, Mickey, B, Malloy, C, Bachoo, R, Deberardinis, R & Maher, E 2013, 'A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors', NMR in Biomedicine, vol. 26, no. 10, pp. 1242-1250. https://doi.org/10.1002/nbm.2943

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abstract = "2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.",

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N2 - 2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

AB - 2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

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