A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage

Lech M. Switalski, Joseph M. Patti, Wade Butcher, Anthony G. Gristina, Pietro Speziale, Magnus Höök

Research output: Contribution to journalArticle

150 Scopus citations

Abstract

Staphylococcus aureus strains isolated from patients with septic arthritis or osteomyelitis possess a collagen receptor present in two forms, which contains either two or three copies of a 187‐amino‐acid repeat motif. Collagen receptor‐positive strains adhered to both collagen substrata and cartilage in a time‐dependent process. Collagen receptor‐specific antibodies blocked bacterial adherence, as did preincubation of the substrate with a recombinant form of the receptor protein. Furthermore, polystyrene beads coated with the collagen receptor bound collagen and attached to cartilage. Taken together, these results suggest that the collagen receptor is both necessary and sufficient to mediate bacterial adherence to cartilage in a process that constitutes an important part of the pathogenic mechanism in septic arthritis.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalMolecular Microbiology
Volume7
Issue number1
DOIs
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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