A chemically synthesized artificial pancreas: Release of insulin from glucose-responsive hydrogels

Anthony Guiseppi-Elie; S. I. Brahim; D. Narinesingh

doi:10.1002/1521-4095(20020517)14:10<743::AID-ADMA743>3.0.CO;2-H

A chemically synthesized artificial pancreas: Release of insulin from glucose-responsive hydrogels

Anthony Guiseppi-Elie, S. I. Brahim, D. Narinesingh

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Contact-lens-like polymeric hydrogels that are glucose-responsive have been synthesized by entrapping the enzyme glucose oxidase (GOx) within the polymer network. The polymeric hydrogeis are pH-sensitive and act as glucoseresponsive membranes effecting the release of insulin (see Figure). The release profile from a multi-laminated hydrogel device displays a sustained release of insulin in response to glucose.

Original language	English (US)
Pages (from-to)	743-746
Number of pages	4
Journal	Advanced Materials
Volume	14
Issue number	10
DOIs	https://doi.org/10.1002/1521-4095(20020517)14:10<743::AID-ADMA743>3.0.CO;2-H
State	Published - May 17 2002

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/1521-4095(20020517)14:10<743::AID-ADMA743>3.0.CO;2-H

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AU - Narinesingh, D.

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Y1 - 2002/5/17

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AB - Contact-lens-like polymeric hydrogels that are glucose-responsive have been synthesized by entrapping the enzyme glucose oxidase (GOx) within the polymer network. The polymeric hydrogeis are pH-sensitive and act as glucoseresponsive membranes effecting the release of insulin (see Figure). The release profile from a multi-laminated hydrogel device displays a sustained release of insulin in response to glucose.

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A chemically synthesized artificial pancreas: Release of insulin from glucose-responsive hydrogels

Abstract

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