A chemically synthesized artificial pancreas: Release of insulin from glucose-responsive hydrogels

Anthony Guiseppi-Elie, S. I. Brahim, D. Narinesingh

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Contact-lens-like polymeric hydrogels that are glucose-responsive have been synthesized by entrapping the enzyme glucose oxidase (GOx) within the polymer network. The polymeric hydrogeis are pH-sensitive and act as glucoseresponsive membranes effecting the release of insulin (see Figure). The release profile from a multi-laminated hydrogel device displays a sustained release of insulin in response to glucose.

Original languageEnglish (US)
Pages (from-to)743-746
Number of pages4
JournalAdvanced Materials
Volume14
Issue number10
DOIs
StatePublished - May 17 2002

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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