Contact-lens-like polymeric hydrogels that are glucose-responsive have been synthesized by entrapping the enzyme glucose oxidase (GOx) within the polymer network. The polymeric hydrogeis are pH-sensitive and act as glucoseresponsive membranes effecting the release of insulin (see Figure). The release profile from a multi-laminated hydrogel device displays a sustained release of insulin in response to glucose.
|Original language||English (US)|
|Number of pages||4|
|State||Published - May 17 2002|
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering