TY - JOUR
T1 - A chemically explicit model for the mechanism of proton pumping in heme-copper oxidases
AU - Sharpe, Martyn A.
AU - Ferguson-Miller, Shelagh
PY - 2008/10
Y1 - 2008/10
N2 - A mechanism for proton pumping is described that is based on chemiosmotic principles and the detailed molecular structures now available for cytochrome oxidases. The importance of conserved water positions and a step-wise gated process of proton translocation is emphasized, where discrete electron transfer events are coupled to proton uptake and expulsion. The trajectory of each pumped proton is the same for all four substrate electrons. An essential role for the His-Tyr cross-linked species is discussed, in gating of the D- and K-channels and as an acceptor/donor of electrons and protons at the binuclear center.
AB - A mechanism for proton pumping is described that is based on chemiosmotic principles and the detailed molecular structures now available for cytochrome oxidases. The importance of conserved water positions and a step-wise gated process of proton translocation is emphasized, where discrete electron transfer events are coupled to proton uptake and expulsion. The trajectory of each pumped proton is the same for all four substrate electrons. An essential role for the His-Tyr cross-linked species is discussed, in gating of the D- and K-channels and as an acceptor/donor of electrons and protons at the binuclear center.
KW - Chemiosmotic principles
KW - Heme-copper oxidases
KW - Proton pumping
UR - http://www.scopus.com/inward/record.url?scp=57049130390&partnerID=8YFLogxK
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U2 - 10.1007/s10863-008-9182-6
DO - 10.1007/s10863-008-9182-6
M3 - Review article
C2 - 18830692
AN - SCOPUS:57049130390
VL - 40
SP - 541
EP - 549
JO - Journal of Bioenergetics and Biomembranes
JF - Journal of Bioenergetics and Biomembranes
SN - 0145-479X
IS - 5
ER -