A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors

Mi-Ran Choi, Katie J Stanton-Maxey, Jennifer K Stanley, Carly S Levin, Rizia Bardhan, Demir Akin, Sunil Badve, Jennifer E. Sturgis, J Paul Robinson, Rashid Bashir, Naomi J. Halas, Susan E Clare

Research output: Contribution to journalArticle

425 Scopus citations

Abstract

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

Original languageEnglish (US)
Pages (from-to)3759-65
Number of pages7
JournalNano Letters
Volume7
Issue number12
DOIs
StatePublished - Dec 2007

Keywords

  • Antineoplastic Agents
  • Biological Transport
  • Cell Hypoxia
  • Drug Delivery Systems
  • Humans
  • Macrophages
  • Monocytes
  • Nanoparticles
  • Neoplasms
  • Spectrophotometry
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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