A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant

Santosh Helekar, Jeffrey L. Noebels

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Hippocampal CA3 pyramidal neurons in the adult epileptic mutant mouse tottering (tg) show normal intrinsic membrane properties, yet fire abnormally prolonged paroxysmal depolarizing shifts (PDS) during in vitro exposure to elevated extracellular potassium solutions. Intracellular recordings in immature mutants reveal that this network burst abnormality is present during the developmental period that coincides with the onset of seizures in the mutant (19-20 postnatal days), and is significantly more pronounced at this age than at adulthood. These data are inconsistent with the hypothesis that the mutant PDS prolongation represents a secondary consequence of a prolonged history of repeated seizures and suggest that it may reflect a cellular epileptogenic phenotype more directly related to the primary neuropathological expression of the tg gene.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalDevelopmental Brain Research
Volume65
Issue number2
DOIs
StatePublished - Feb 21 1992

Keywords

  • Afterhyperpolarization
  • CA3 pyramidal neuron
  • Epilepsy
  • Paroxysmal depolarizing shift
  • Seizure-induced plasticity

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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