A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer

Richard J. Robbins, Jessica S. Thomas, Patricia Mejia Osuna, Jawairia Shakil

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common RET mutations but did harbor a BRAF V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We conclude that this common BRAF mutation may independently drive neoplastic transformation of human parafollicular C cells.

Original languageEnglish (US)
Article number7641940
JournalCase Reports in Endocrinology
StatePublished - 2020

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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