Abstract
We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common RET mutations but did harbor a BRAF V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We conclude that this common BRAF mutation may independently drive neoplastic transformation of human parafollicular C cells.
Original language | English (US) |
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Article number | 7641940 |
Journal | Case Reports in Endocrinology |
Volume | 2020 |
DOIs | |
State | Published - 2020 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism