A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

Li Quan; Jianhua Gu; Wenhai Lin; Yanchun Wei; Yuebin Lin; Lei Liu; Hongyan DIng; Changjiang Pan; Zhigang Xie; Tianfu Wu

doi:10.1039/c9cc03810h

A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

Li Quan, Jianhua Gu, Wenhai Lin, Yanchun Wei, Yuebin Lin, Lei Liu, Hongyan DIng, Changjiang Pan, Zhigang Xie, Tianfu Wu

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.

Original language	English (US)
Pages (from-to)	8564-8566
Number of pages	3
Journal	Chemical Communications
Volume	55
Issue number	59
DOIs	https://doi.org/10.1039/c9cc03810h
State	Published - Jul 18 2019

Keywords

Biosensing Techniques/methods
Boron Compounds/chemical synthesis
Fluorescent Dyes/chemical synthesis
Nanofibers/chemistry
Phenylalanine/analogs & derivatives
Protein Multimerization

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc03810h

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title = "A BODIPY biosensor to detect and drive self-assembly of diphenylalanine",

abstract = "Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.",

keywords = "Biosensing Techniques/methods, Boron Compounds/chemical synthesis, Fluorescent Dyes/chemical synthesis, Nanofibers/chemistry, Phenylalanine/analogs \& derivatives, Protein Multimerization",

author = "Li Quan and Jianhua Gu and Wenhai Lin and Yanchun Wei and Yuebin Lin and Lei Liu and Hongyan DIng and Changjiang Pan and Zhigang Xie and Tianfu Wu",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

month = jul,

day = "18",

doi = "10.1039/c9cc03810h",

language = "English (US)",

volume = "55",

pages = "8564--8566",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

AU - Quan, Li

AU - Gu, Jianhua

AU - Lin, Wenhai

AU - Wei, Yanchun

AU - Lin, Yuebin

AU - Liu, Lei

AU - DIng, Hongyan

AU - Pan, Changjiang

AU - Xie, Zhigang

AU - Wu, Tianfu

PY - 2019/7/18

Y1 - 2019/7/18

N2 - Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.

AB - Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.

KW - Biosensing Techniques/methods

KW - Boron Compounds/chemical synthesis

KW - Fluorescent Dyes/chemical synthesis

KW - Nanofibers/chemistry

KW - Phenylalanine/analogs & derivatives

KW - Protein Multimerization

UR - https://www.scopus.com/pages/publications/85069458023

UR - https://www.scopus.com/inward/citedby.url?scp=85069458023&partnerID=8YFLogxK

U2 - 10.1039/c9cc03810h

DO - 10.1039/c9cc03810h

M3 - Article

C2 - 31271158

AN - SCOPUS:85069458023

SN - 1359-7345

VL - 55

SP - 8564

EP - 8566

JO - Chemical Communications

JF - Chemical Communications

IS - 59

ER -

A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

Abstract

Keywords

ASJC Scopus subject areas

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