A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

Li Quan, Jianhua Gu, Wenhai Lin, Yanchun Wei, Yuebin Lin, Lei Liu, Hongyan DIng, Changjiang Pan, Zhigang Xie, Tianfu Wu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.

Original languageEnglish (US)
Pages (from-to)8564-8566
Number of pages3
JournalChemical Communications
Volume55
Issue number59
DOIs
StatePublished - Jul 18 2019

Keywords

  • Biosensing Techniques/methods
  • Boron Compounds/chemical synthesis
  • Fluorescent Dyes/chemical synthesis
  • Nanofibers/chemistry
  • Phenylalanine/analogs & derivatives
  • Protein Multimerization

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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