A 96-well, plate-based microfluidic device for multiplexed chemosensitivity testing on intact tissues

T. Chang, Andrei M Mikheev, R. J. Monnat, Robert C. Rostomily, A. Folch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

This paper reports the development of a novel drug testing platform that uses intact tumor tissue in a 96-well, plate- based microfluidic device. This device was reported at μTAS12 [1]. Here, we incorporate a new eulture membrane transfer technique that enables the culture, drug exposure, and post-exposure tissue processing to be separated into three platforms (Fig. la-c). The result of our Tcmozolomide(TMZ) drug testing on Glioblastoma Multiforme (GBM) xenograft sliccs demonstrate the feasibility of using this platform to identify effective chcmotherapcutic drugs for specific tumors and patients to guide therapeutic decision-making.

Original languageEnglish (US)
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages506-508
Number of pages3
Volume1
ISBN (Print)9781632666246
StatePublished - 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: Oct 27 2013Oct 31 2013

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period10/27/1310/31/13

Keywords

  • Cancer
  • Microfluidics
  • Organotypic slice culture
  • Personalized chemotherapy
  • Tumor

ASJC Scopus subject areas

  • Bioengineering

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