Abstract
This paper reports the development of a novel drug testing platform that uses intact tumor tissue in a 96-well, plate- based microfluidic device. This device was reported at μTAS12 [1]. Here, we incorporate a new eulture membrane transfer technique that enables the culture, drug exposure, and post-exposure tissue processing to be separated into three platforms (Fig. la-c). The result of our Tcmozolomide(TMZ) drug testing on Glioblastoma Multiforme (GBM) xenograft sliccs demonstrate the feasibility of using this platform to identify effective chcmotherapcutic drugs for specific tumors and patients to guide therapeutic decision-making.
| Original language | English (US) |
|---|---|
| Title of host publication | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 506-508 |
| Number of pages | 3 |
| Volume | 1 |
| ISBN (Print) | 9781632666246 |
| State | Published - 2013 |
| Event | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany Duration: Oct 27 2013 → Oct 31 2013 |
Other
| Other | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 |
|---|---|
| Country | Germany |
| City | Freiburg |
| Period | 10/27/13 → 10/31/13 |
Keywords
- Cancer
- Microfluidics
- Organotypic slice culture
- Personalized chemotherapy
- Tumor
ASJC Scopus subject areas
- Bioengineering