A 17-year study of bloodstream Escherichia coli infection after liver transplantation: Resistance rate, risk factor and mortality

Qiang Tai, Xiao Shun He, An Bin Hu, Lin Wei Wu, Wei Qiang Ju, Xiao Feng Zhu, Dong Ping Wang, Guo Dong Wang, Yi Ma, Zhi Yong Guo, Jie Fu Huang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To explore the resistance rate, risk factors and mortality of Escherichia coli bloodstream infections (BSI) after liver transplantation. Methods: From January 1993 to May 2010, a retrospective analysis of Escherichia coli in liver transplants were conducted. Results: A total of 88 BSI occurred in 83/695 patients and Escherichia coli (n = 23) was most commonly found. Carbapenem and piperacillin-tazobactam were the most consistentiy active against Escherichia coli while the resistance rate to enterococcus for ciprofloxacin, gentamycin, ampicillin-clavulanic acid was over 60%. Univariate analysis identified the following variables as risk factors for Escherichia coli bacteremia: cholangioenterostomy (P < 0.001) and ductal complications (F < 0.001). Escherichia coli bloodstream infection could increase the mortality at 15 days after bloodstream infection. No significant difference in mortality occurred at 30 days and 1 year after enterococcal bacteremia. Conclusion: Escherichia coli after liver transplantation is resistant to agents but commonly active to carbapenem and piperacillin-tazobactam. The risk factor associated with Escherichia coli bloodstream infections are cholangioenterostomy and ductal complications. Escherichia coli bloodstream infection can increase the mortality at 15 days after bloodstream infection.

Original languageEnglish (US)
Pages (from-to)2977-2980
Number of pages4
JournalNational Medical Journal of China
Volume91
Issue number42
DOIs
StatePublished - Nov 15 2011

Keywords

  • Bloodstream infection
  • Escherichia
  • Mortality
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

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